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| Status |
Public on Nov 06, 2020 |
| Title |
Anatomical diversity of dermis in homeostasis and wound repair |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Skin has distinct characteristics depending on the anatomical site; however, the cell and molecular differences, and their functional implications, have been little described. RNA-sequencing of healthy adult mouse skin from the abdomen, back, and face/cheek has revealed that dermis from different sites is distinct, and that this aligns with their diverse embryonic origins (abdominal dermis develops from lateral plate mesoderm, dorsal dermis from paraxial mesoderm, and cheek dermis from neural crest). The functional implications for wound repair are evident from the differences in extracellular matrix and cell migration observed in tissue and dermal fibroblasts from these sites, and the histological and transcriptional variations during a wound response.
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| Overall design |
24 samples have been analysed by RNA-seq (total RNA): 4 mice for each of 3 anatomical sites (abdomen, back, cheek), and each mouse included a Day3 full-thickness 2mm punch-biopsy skin wound and an adjacent unwounded "paired" control.
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| Contributor(s) |
Shaw TJ, Jaworska P, Sofra V, Song H, Logan M, Graham A |
| Citation(s) |
33197044 |
| Submission date |
Jun 04, 2020 |
| Last update date |
Feb 05, 2021 |
| Contact name |
Tanya J Shaw |
| E-mail(s) |
tanya.shaw@kcl.ac.uk
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| Organization name |
King's College London
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| Department |
Centre for Inflammation Biology & Cancer Immunology
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| Street address |
Guy's Campus, New Hunt's House, Great Maze Pond
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| City |
London |
| ZIP/Postal code |
SE1 1UL |
| Country |
United Kingdom |
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| Platforms (1) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA637413 |
| SRA |
SRP266041 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151850_AllSamples.GeneExpression.FPKM.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE151850_All_comparisons.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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