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Series GSE152035 Query DataSets for GSE152035
Status Public on Dec 09, 2020
Title Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate Heterogeneity of Histopathology, Molecular Signatures and Drug Response
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary We established 21 patient-derived pHGG orthotopic xenograft (PDOX) models and 8 matched cell lines from diverse pHGG subgroups. Models recapitulated histopathology, DNA methylation signatures, mutations and gene expression patterns of the patient tumors from which they were derived, and included rare subgroups not well-represented by existing models. We also included 6 DIPG cell lines generously shared by Dr. Michelle Monje (Stanford University). An online interactive data portal is available to explore associated detailed molecular characterization and HTS chemical sensitivity data.
 
Overall design Bisulphite converted DNA from these samples were hybridised to the Illumina Infinium MethylationEPIC or HumanMethylation450 BeadChip
 
Contributor(s) Gudenas B, Xu K, Baker SJ
Citation(s) 34215733
Submission date Jun 08, 2020
Last update date Jul 27, 2021
Contact name Suzanne J. Baker
E-mail(s) Suzanne.Baker@STJUDE.ORG
Organization name ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Street address 262 Danny Thomas Place
City MEMPHIS
State/province TENNESSEE
ZIP/Postal code 38105
Country USA
 
Platforms (2)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
GPL21145 Infinium MethylationEPIC
Samples (55)
GSM4600796 201525200072_R02C01
GSM4600797 201525200072_R03C01
GSM4600798 201525200072_R06C01
Relations
BioProject PRJNA638139

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE152035_HGG_processed_450k.csv.gz 17.1 Mb (ftp)(http) CSV
GSE152035_HGG_processed_850k.csv.gz 336.7 Mb (ftp)(http) CSV
GSE152035_HGG_signal_450k.csv.gz 21.8 Mb (ftp)(http) CSV
GSE152035_HGG_signal_850k.csv.gz 672.3 Mb (ftp)(http) CSV
GSE152035_RAW.tar 1.1 Gb (http)(custom) TAR (of IDAT)
Processed data are available on Series record

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