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Series GSE152224 Query DataSets for GSE152224
Status Public on Jun 01, 2021
Title Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary We identified a new brain-specific isoform of PGC1 α that is the main isoform in neurons. Mutation of this gene leads to a sex dimorphic gene expression program in the female cerebellum and to alter motor coordination
Overall design We utilized microarrays to establish the differential gene expression program in the cerebellum or rest of brain (whole brain minus cerebellum) in WT and mutant littermates; males and females were separately profiled.
Contributor(s) Santos JH
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Submission date Jun 10, 2020
Last update date Jun 03, 2021
Contact name NIEHS Microarray Core
Organization name NIEHS
Department DIR
Lab Microarray Core
Street address 111 T.W. Alexander Drive
City RTP
State/province NC
ZIP/Postal code 27709
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (16)
GSM4609548 WT cb female rep1
GSM4609549 WT cb female rep2
GSM4609550 WT cb male rep1
BioProject PRJNA638655

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE152224_RAW.tar 64.1 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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