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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 13, 2020 |
| Title |
Impact of chronic extracellular acidosis on gene expression in mammary and pancreatic cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The study aim was to determine whether the microenvironmental acidosis in solid tumors contributes to cancer aggressiveness via changes in gene expression. RNA seq was carried out in parallel to a large array of phenotypical analyses of proliferation, growth, and invasiveness.
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| Overall design |
3 human cancer cell lines (2 mammary, 1 pancreatic) adapted for 1-2 months to growth at extracellular pH 7.6 and 6.5, respectively, were subjected to RNA sequencing (BGI Hongkong), each in triplicates.
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| Contributor(s) |
Rolver MG, Schnipper J, Yao J, Ialchina R, Czaplinska D, Pedersen SF, Sandelin A |
| Citation(s) |
32764426, 36533672 |
| Submission date |
Jun 12, 2020 |
| Last update date |
May 12, 2023 |
| Contact name |
Jiayi Yao |
| E-mail(s) |
jiayi.yao@bio.ku.dk
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| Organization name |
University of Copenhagen
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| Street address |
Ole Maaløes Vej 5
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| City |
Copenhagen |
| State/province |
Copenhangen |
| ZIP/Postal code |
2200 |
| Country |
Denmark |
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| Platforms (1) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA639069 |
| SRA |
SRP267051 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE152345_RAW.tar |
4.0 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE152345_gene_level_quantification.txt.gz |
906.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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