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| Status |
Public on Sep 30, 2009 |
| Title |
Hormone effects on gene expression in somatic cells of rat testes (Rattus norvegicus) |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of hormone effects on irradiated LBNF1 rat testes, which contain only somatic cells except for a few type A spermatgogonia. Rats were treated for 2 weeks with either sham treatment (group X), hormonal ablation (GnRH antagonist and the androgen receptor antagonist flutamide, group XAF), testosterone supplementation (GnRH antagonist and testosterone, group XAT), and FSH supplementation ((GnRH antagonist, androgen receptor antagonist, and FSH, group XAFF). Results provide insight into identifying genes in the somatic testis cells regulated by testosterone, LH, or FSH.
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| Overall design |
14 Sample replicates of sham treatment, 11 Sample replicates of hormonal ablation, 5 Sample replicates of testosterone supplementation, and 5 Sample replicates of FSH supplementation were studied.
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| Contributor(s) |
Zhou W, Bolden-Tiller OU, Shetty G, Shao SH, Weng CC, Pakarinen P, Liu Z, Stivers DN, Meistrich ML |
| Citation(s) |
19684331 |
| Submission date |
Mar 16, 2009 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Wei Zhou |
| E-mail(s) |
wzhou@mdanderson.org
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| Fax |
7137945369
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| Organization name |
M.D.Anderson Cancer Center
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| Department |
Department of Experimental Radiation Oncology
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| Street address |
1515 Holcombe Blvd
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (35)
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| GSM380550 |
Irradiated rat testes, with sham treatment, biological rep 1 |
| GSM380551 |
Irradiated rat testes, with sham treatment, biological rep 2 |
| GSM380552 |
Irradiated rat testes, with sham treatment, biological rep 3 |
| GSM380553 |
Irradiated rat testes, with sham treatment, biological rep 4 |
| GSM380554 |
Irradiated rat testes, with sham treatment, biological rep 5 |
| GSM380555 |
Irradiated rat testes, with sham treatment, biological rep 6 |
| GSM380556 |
Irradiated rat testes, with sham treatment, biological rep 7 |
| GSM380557 |
Irradiated rat testes, with sham treatment, biological rep 8 |
| GSM380558 |
Irradiated rat testes, with sham treatment, biological rep 9 |
| GSM380559 |
Irradiated rat testes, with sham treatment, biological rep 10 |
| GSM380560 |
Irradiated rat testes, with sham treatment, biological rep 11 |
| GSM380561 |
Irradiated rat testes, with sham treatment, biological rep 12 |
| GSM380562 |
Irradiated rat testes, with sham treatment, biological rep 13 |
| GSM380563 |
Irradiated rat testes, with sham treatment, biological rep 14 |
| GSM380564 |
Irradiated rat testes, with hormonal ablation, biological rep 1 |
| GSM380565 |
Irradiated rat testes, with hormonal ablation, biological rep 2 |
| GSM380566 |
Irradiated rat testes, with hormonal ablation, biological rep 3 |
| GSM380567 |
Irradiated rat testes, with hormonal ablation, biological rep 4 |
| GSM380568 |
Irradiated rat testes, with hormonal ablation, biological rep 5 |
| GSM380569 |
Irradiated rat testes, with hormonal ablation, biological rep 6 |
| GSM380570 |
Irradiated rat testes, with hormonal ablation, biological rep 7 |
| GSM380571 |
Irradiated rat testes, with hormonal ablation, biological rep 8 |
| GSM380572 |
Irradiated rat testes, with hormonal ablation, biological rep 9 |
| GSM380573 |
Irradiated rat testes, with hormonal ablation, biological rep 10 |
| GSM380574 |
Irradiated rat testes, with hormonal ablation, biological rep 11 |
| GSM380575 |
Irradiated rat testes, with testosterone supplementation, biological rep 1 |
| GSM380576 |
Irradiated rat testes, with testosterone supplementation, biological rep 2 |
| GSM380577 |
Irradiated rat testes, with testosterone supplementation, biological rep 3 |
| GSM380578 |
Irradiated rat testes, with testosterone supplementation, biological rep 4 |
| GSM380579 |
Irradiated rat testes, with testosterone supplementation, biological rep 5 |
| GSM380580 |
Irradiated rat testes, with FSH supplementation, biological rep 1 |
| GSM380581 |
Irradiated rat testes, with FSH supplementation, biological rep 2 |
| GSM380582 |
Irradiated rat testes, with FSH supplementation, biological rep 3 |
| GSM380583 |
Irradiated rat testes, with FSH supplementation, biological rep 4 |
| GSM380584 |
Irradiated rat testes, with FSH supplementation, biological rep 5 |
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| Relations |
| BioProject |
PRJNA116529 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE15243_RAW.tar |
90.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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