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Series GSE15248 Query DataSets for GSE15248
Status Public on Mar 13, 2010
Title Biocompatibility and Discovery of the Potential Applications of Magnetite (Fe3O4) Nanoparticles
Organism Homo sapiens
Experiment type Expression profiling by array
Summary A Transcriptomics Approach to Study the Biocompatibility and Finding out the Potential Applications of Magnetite (Fe3O4) Nanoparticles
Here in this study, we examine the molecular effects of uptake of Fe3O4 nanoparticles using a whole genome microarray study in human epithelial cancer cell line. 38 genes (55%) out of 69 downregulated genes were found to be associated with TGF-beta or BMP signaling including six genes, Id1, Id2, Id3, Caspase-9, Smad6 and SMAD7, important negative regulators of these signaling pathways involved in development and tumorigenesis.
 
Overall design Total RNA isolated from MNP treated HeLa cells compared to untreated controls.
 
Contributor(s) Khan JA, Mandal TK, Das TK, Singh Y, Maiti S, Pillai B
Citation(s) 21336377
Submission date Mar 16, 2009
Last update date Feb 15, 2013
Contact name Jameel Ahmad Khan
E-mail(s) khanjahmad@yahoo.com
Organization name Institute Of Genomics and Integrative Biology (CSIR)
Street address Mall Road
City Delhi
State/province Delhi
ZIP/Postal code 110007
Country India
 
Platforms (1)
GPL6102 Illumina human-6 v2.0 expression beadchip
Samples (6)
GSM380869 Control Rep1
GSM380870 Control Rep2
GSM380871 Control Rep3
Relations
BioProject PRJNA116539

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15248_RAW.tar 5.8 Mb (http)(custom) TAR
GSE15248_un-normalizedDataMatrix.txt 3.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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