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Series GSE152630 Query DataSets for GSE152630
Status Public on Sep 07, 2021
Title Cobalt Induced Oxidative Stress Contributes to Alveolar/Bronchiolar Carcinogenesis in B6C3F1/N Mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary To identify differentially expressed transcripts between control samples and spontaneous tumors, or control samples and cobalt treated tumors, we collected RNA from male and female B6C3F1 mice from a 2-year inhalation NTP bioassay exposed to 0 or 5 mg/m3 cobalt metal dust. These samples were interrogated with the Affymetrix Mouse Genome 430 2.0 GeneChip Array.
A total of 11557 gene transcripts were differentially expressed between control samples and spontaneous tumors, and 12420 gene transcripts were differentially expressed between control samples and treated cobalt tumors (false discovery rate (FDR) < 0.05).
 
Overall design There were 3 groups and 6x replication for each group, for 18 total samples. The groups were (1) vehicle control, (2) spontaneous tumors, (3) tumors present with cobalt treatment. We compared vehicle control vs spontaneous tumor and control vs treated tumor using ORIOGEN software. The permutation based p-values for each test were significant for FDR≤5%.
 
Contributor(s) Shockley KR, Pandiri AR
Citation(s) 34468815
Submission date Jun 16, 2020
Last update date Sep 08, 2021
Contact name Keith Shockley
Organization name NIEHS
Street address 111 TW Alexander Drive
City RTP
State/province NC
ZIP/Postal code 27709
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (18)
GSM4618918 CONTROL_rep1 (cobalt)
GSM4618919 CONTROL_rep2 (cobalt)
GSM4618920 CONTROL_rep3 (cobalt)
Relations
BioProject PRJNA639854

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE152630_RAW.tar 66.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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