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Status |
Public on Aug 19, 2020 |
Title |
Epigenome analysis of low-grade neuroepithelial tumors with FGFR1 alterations |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by genome tiling array
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Summary |
Genome-wide DNA methylation profiling of 30 low-grade neuroepithelial tumors with FGFR1 alterations including rosette-forming glioneuronal tumor, pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor, and extraventricular neurocytoma. The Illumina Infinium EPIC 850k Human DNA Methylation Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpG sites of genomic DNA extracted from formalin-fixed, paraffin-embedded tumor tissue of 30 low-grade neuroepithelial tumors with FGFR1 alterations including kinase domain tandem duplication, in-frame fusion with TACC1, and hotspot missense mutation within the intracellular tyrosine kinase domain.
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Overall design |
Bisulfite converted genomic DNA extracted from the 30 tumor samples was hybridized to Illumina Infinium EPIC 850k Human DNA Methylation Beadchip
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Contributor(s) |
Solomon DA |
Citation(s) |
32859279 |
NIH grant(s) |
Grant ID |
Grant title |
Affiliation |
Name |
DP5 OD021403 |
Cohesin gene mutations in tumorigenesis |
University of California San Francisco |
David A. Solomon |
P50 CA097257 |
Brain Tumor SPORE Grant |
University of California San Francisco |
MITCHEL S. BERGER |
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Submission date |
Jun 17, 2020 |
Last update date |
Aug 31, 2020 |
Contact name |
David A. Solomon |
E-mail(s) |
david.solomon@ucsf.edu
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Organization name |
University of California, San Francisco
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Department |
Pathology
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Street address |
513 Parnassus Ave, HSW 451
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City |
San Francisco |
State/province |
CA |
ZIP/Postal code |
94143 |
Country |
USA |
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Platforms (1) |
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Samples (30)
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Relations |
BioProject |
PRJNA639971 |