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| Status |
Public on Apr 22, 2021 |
| Title |
eATP-responsive synthetic yeast ameliorate TNBS-induced colitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
By combining directed evolution and synthetic biology, we engineered novel synthetic yeasts probiotics for the dynamic modulation of intestinal inflammation. In this experiment we treated TNBS-colitis induced mice with these probiotics and test the amelioration of immune response in the transcriptional level in the colon.
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| Overall design |
A colon piece was colected from each mouse at the peak of the diesease for transcriptional analysis. Control groups were included.
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| Contributor(s) |
Gutierrez-Vazquez C, Li Z, Quintana FJ |
| Citation missing |
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| Submission date |
Jun 19, 2020 |
| Last update date |
Apr 24, 2021 |
| Contact name |
Zhaorong Li |
| E-mail(s) |
zhaorong@bu.edu
|
| Organization name |
Brigham and Women's Hospital
|
| Street address |
60 Fenwood Road
|
| City |
Boston |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA640672 |
| SRA |
SRP268073 |
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