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| Status |
Public on Feb 17, 2022 |
| Title |
Mammalian PERIOD2 regulates H2A.Z incorporation into chromatin to orchestrate circadian negative feedback [Mnase-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We report the interdependance of PERIOD and H2A.Z to orchestrated the circadian negative feedback. H2A.Z is required for the circadian rhythm, it allows the binding of Bmal1 and PERIOD2 to the chromatin. And reciprocally, PERIOD2 aid H2A.Z deposition by interacting with the specific chaperone YL1.
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| Overall design |
Mnase-seq between wildtype and period triple KO or H2A.Z double KO MEF cells
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| |
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| Contributor(s) |
Tartour K, Andriani F, Folco EJ, Padmanabhan K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 07, 2020 |
| Last update date |
Feb 17, 2022 |
| Contact name |
Kiran Padmanabhan |
| E-mail(s) |
kiran.padmanabhan@ens-lyon.fr
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| Organization name |
ENS-Lyon
|
| Department |
IGFL
|
| Street address |
32-34 avenue Tony Garnier
|
| City |
Lyon |
| ZIP/Postal code |
69007 |
| Country |
France |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE153939 |
Mammalian PERIOD2 regulates H2A.Z incorporation into chromatin to orchestrate circadian negative feedback |
|
| Relations |
| BioProject |
PRJNA644585 |
| SRA |
SRP270655 |
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