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Series GSE154980 Query DataSets for GSE154980
Status Public on Dec 15, 2021
Title Epigenome analysis of muscle tissue samples from male participants of the Hertfordshire Sarcopenia Study (HSS) and Hertfordshire Sarcopenia Study extension (HSSe)
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Genome wide DNA methylation profiling of muscle tissue genomic DNA. The Illumina Infinium MethylationEPIC array was used to obtain DNA methylation profiles across approximately 850,000 CpGs. Samples were male, taken from both the Hertfordshire Sarcopenia Study (HSS, n=34) and the Hertfordshire Sarcoepnia Study exension (HSSe, n=44), to determine DNA methylation associations with measures of muscle mass and function. We further aimed to test whether differences in the muscle methylome are associated with sarcopenia in older individuals. We found significant associations between DNA methylation in the muscle tissue and sarcopenia, as well as individual measures of muscle mass and function, enriched around EZH2 binding sites.
 
Overall design Bisulphite converted DNA from the 78 samples were hybridised to the Illumina Human Infinium MethylationEPIC array
 
Contributor(s) Antoun E
Citation(s) 34862756
Submission date Jul 23, 2020
Last update date Dec 18, 2021
Contact name Elie Antoun
Organization name University of Oxford
Department CAMS China Oxford Institute (CAMS-COI
Street address Nuffield Department of Medicine
City Oxford
State/province United Kingdom
ZIP/Postal code OX3 7BN
Country United Kingdom
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (78)
GSM4685309 [EPIC] genomic DNA from muscle sample 1
GSM4685310 [EPIC] genomic DNA from muscle sample 2
GSM4685311 [EPIC] genomic DNA from muscle sample 3
Relations
BioProject PRJNA648122

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE154980_RAW.tar 1.2 Gb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
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