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| Status |
Public on Apr 07, 2021 |
| Title |
Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
transcriptional profiling was performed on Regnase-1 KO CAR and Regnase-1 TCF-1 DKO CAR T cells isolated 7days after co-transfer into tumor bearing mice.
TCF-1 deficiency in Regnase-1 KO CAR T cells led to reduced long-term persistence and memory-like phenotype.
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| |
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| Overall design |
In total 10 samples were analyzed: (KO CAR n=5; DKO CAR n=5)
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| |
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| Contributor(s) |
Wenting Z, Dhungana Y, Terrence G |
| Citation(s) |
33690816 |
| Submission date |
Jul 23, 2020 |
| Last update date |
Apr 10, 2021 |
| Contact name |
Hongbo Chi |
| E-mail(s) |
hongbo.chi@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Immunology
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE155021 |
Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL |
|
| Relations |
| BioProject |
PRJNA648160 |
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