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| Status |
Public on Jan 03, 2005 |
| Title |
Terminal heart failure |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Rats overexpressing the human renin and angiotensinogen genes die after seven weeks of end organ damage. They develop hypertension, heart hypertrophy and proteinuria.We compared terminal heart failure, these are indeed terminally ill to double transgenic animals suffering on hypertension, proteinuria and heart hypertrophy. In addition, Losartan-treated animals (10 mg/kg/d)showed similar physiological parameters (normotension, no proteinuria and no heart hypertrophy compared to control sprague dawley rats.
Keywords: other
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| Contributor(s) |
Wellner M, Dechend R, Park J, Shagdarsuren E, Al-Saadi N, Meiners S, Kirsch T, Fiebeler A, Haller H, Luft FC, Muller DN |
| Citation(s) |
15623567 |
| Submission date |
Jul 12, 2004 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Maren Wellner |
| E-mail(s) |
wellner@fvk-berlin.de
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| Phone |
03094062503
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| Organization name |
Franz-Volhard-Klinik am Max-Delbrück-Centrum
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| Street address |
Robert-Rössle-Str. 10
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| City |
Berlin |
| ZIP/Postal code |
13125 |
| Country |
Germany |
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| Platforms (1) |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA90867 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE1557_RAW.tar |
7.3 Mb |
(http)(custom) |
TAR (of CEL, EXP) |
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