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Series GSE1562 Query DataSets for GSE1562
Status Public on Jan 01, 2005
Title Adenovirus-mediated E2F-1 gene transfer in melanoma cell line
Organism Homo sapiens
Experiment type Expression profiling by array
Summary E2F-1 gene expression profiling by adenovirus-mediated gene transfer in SKMEL-2 melanoma cell line.
Keywords: other
 
 
Contributor(s) McMasters K, Jamshidi-Parsian A, Dong Y, Zhou H
Citation(s) 15656974
Submission date Jul 14, 2004
Last update date Dec 13, 2018
Contact name Kelly M McMasters
E-mail(s) ajjams01@gwise.louisville.edu
Phone (502)852-3793
Fax (502)852-2356
Organization name University Of Louisville
Department Surgery
Lab Surgical Oncology
Street address 580 South Preston, Room# 326
City Louisville
State/province KY
ZIP/Postal code 40202
Country USA
 
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (4)
GSM24425 LacZ, #1 repeat
GSM24426 E2F-1, #1 repeat
GSM24427 LacZ, #2 repeat
Relations
BioProject PRJNA90877

Table of 452 genes with over 2-fold change in Ad-E2F-1 gene-transferred vs LAC-Z control. (SK-MEL-2 melanoma cells). (Row 3-Row 286 are up-regulated, Row 287-Row 454 are down-regulated) header descriptions
Affymetrix #
Ave. Fold Change (calculated from SLR)
Ave. Dev.(from SLR ave. dev.)
Gene Title
Gene Symbol
GO Biological Process Description
GO Molecular Function Description
GO Cellular Component Description
Pathway
Pathway Hyperlink

Data table
Affymetrix # Ave. Fold Change (calculated from SLR) Ave. Dev.(from SLR ave. dev.) Gene Title Gene Symbol GO Biological Process Description GO Molecular Function Description GO Cellular Component Description Pathway Pathway Hyperlink
37141_at 46.9 46.9 1.04 forkhead box A1 FOXA1 regulation of transcription, DNA-dependent transcription factor activity nucleus --- ---
1113_at 30.9 30.9 1.19 bone morphogenetic protein 2 BMP2 skeletal development /// cell-cell signaling /// cell growth and/or maintenance /// growth cytokine activity /// growth factor activity extracellular --- ---
38545_at 24.3 24.3 1.87 inhibin, beta B (activin AB beta polypeptide) INHBB ovarian follicle development /// regulation of transcription, DNA-dependent /// cell-cell signaling /// cell growth and/or maintenance /// response to external stimulus /// cell differentiation /// growth /// positive regulation of follicle-stimulating hormone secretion /// negative regulation of follicle-stimulating hormone secretion /// negative regulation of hepatocyte growth factor biosynthesis DNA binding /// defense/immunity protein activity /// cytokine activity /// hormone activity /// protein binding /// growth factor activity /// protein homodimerization activity /// host cell surface receptor binding extracellular /// nucleus --- ---
31805_at 22.6 22.6 2.14 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) FGFR3 MAPKKK cascade /// skeletal development /// oncogenesis /// JAK-STAT cascade /// FGF receptor signaling pathway fibroblast growth factor receptor activity integral to plasma membrane --- ---
38248_at 20.4 20.4 1.37 ProSAPiP1 protein ProSAPiP1 --- --- --- --- ---
36319_at 19.7 19.7 1.15 forkhead box F2 FOXF2 regulation of transcription, DNA-dependent /// transcription from Pol II promoter transcription factor activity /// RNA polymerase II transcription factor activity /// transcription coactivator activity nucleus /// transcription factor complex --- ---
2042_s_at 18.4 18.4 1.15 v-myb myeloblastosis viral oncogene homolog (avian) MYB --- myb_DNA-binding;DNA binding;5.2e-17 --- --- ---
40367_at 16.6 16.6 1.11 bone morphogenetic protein 2 BMP2 skeletal development /// cell-cell signaling /// cell growth and/or maintenance /// growth cytokine activity /// growth factor activity extracellular --- ---
40528_at 16.0 16.0 1.07 LIM homeobox 2 LHX2 regulation of transcription, DNA-dependent transcription factor activity nucleus --- ---
34585_at 13.0 13.0 1.23 distal-less homeo box 2 DLX2 regulation of transcription, DNA-dependent /// development /// brain development transcription factor activity nucleus --- ---
40472_at 10.9 10.9 1.37 PlSC domain containing hypothetical protein LOC254531 --- --- --- --- ---
35249_at 10.6 10.6 1.07 cyclin E2 CCNE2 --- --- --- Cell_Cycle www.genmapp.org/MAPPSet-Human/KEGG_Pathway_MAPPs/Hs_Cell_Cycle.htm
32649_at 9.2 9.2 1.23 transcription factor 7 (T-cell specific, HMG-box) TCF7 --- HMG_box;DNA binding;8.8e-30 --- --- ---
34335_at 8.6 8.6 1.15 ephrin-B2 EFNB2 cell-cell signaling /// neurogenesis /// morphogenesis ephrin receptor binding integral to plasma membrane /// Ephrin;membrane;1.2e-91 --- ---
36053_at 8.6 8.6 2.30 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) CDKN2C cell cycle /// cell cycle arrest /// negative regulation of cell proliferation cyclin-dependent protein kinase inhibitor activity nucleus /// cytoplasm --- ---
32570_at 8.3 8.3 1.04 hydroxyprostaglandin dehydrogenase 15-(NAD) HPGD prostaglandin metabolism /// metabolism prostaglandin-D synthase activity /// electron transporter activity /// 15-hydroxyprostaglandin dehydrogenase (NAD+) activity /// oxidoreductase activity --- --- ---
34982_at 8.3 8.3 2.93 cytochrome P450, family 26, subfamily A, polypeptide 1 CYP26A1 electron transport electron transporter activity /// retinoic acid 4-hydroxylase activity /// oxygen binding endoplasmic reticulum /// microsome /// membrane --- ---
40314_at 8.3 8.3 1.68 synaptogyrin 3 SYNGR3 --- --- integral to plasma membrane /// MARVEL;membrane;7.4e-50 --- ---
36548_at 8.0 8.0 2.14 KIAA0895 protein KIAA0895 --- --- --- --- ---
35663_at 7.7 7.7 1.93 neuronal pentraxin II NPTX2 heterophilic cell adhesion /// regulation of synapse sugar binding --- --- ---

Total number of rows: 452

Table truncated, full table size 91 Kbytes.




Table of all 3329 changed genes in Ad-E2F-1 gene transferred vs LAC-Z control. (SK-MEL-2 melanoma cells) header descriptions
Probe Set ID
Gene Title
Gene Symbol
GO Biological Process Description
GO Molecular Function Description
GO Cellular Component Description
Pathway
Pathway Hyperlink

Data table
Probe Set ID Gene Title Gene Symbol GO Biological Process Description GO Molecular Function Description GO Cellular Component Description Pathway Pathway Hyperlink
1104_s_at --- --- --- --- --- --- ---
1119_at replication protein A2, 32kDa RPA2 DNA dependent DNA replication nucleic acid binding /// single-stranded DNA binding nucleus /// DNA replication factor A complex --- ---
1126_s_at --- --- --- Xlink;hyaluronic acid binding;3.6e-44 --- --- ---
1191_s_at proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 PSMD11 --- --- cytosol --- ---
1211_s_at CASP2 and RIPK1 domain containing adaptor with death domain CRADD apoptosis /// signal transduction /// induction of apoptosis via death domain receptors protein binding /// apoptosis regulator activity intracellular --- ---
1227_g_at a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) ADAM17 proteolysis and peptidolysis /// cell-cell signaling metalloendopeptidase activity /// zinc ion binding /// hydrolase activity integral to plasma membrane --- ---
1235_at tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide YWHAZ --- protein domain specific binding --- --- ---
1237_at immediate early response 3 IER3 apoptosis /// anti-apoptosis /// embryogenesis and morphogenesis /// cell growth and/or maintenance apoptosis inhibitor activity --- --- ---
1245_i_at p21 (CDKN1A)-activated kinase 2 PAK2 protein amino acid phosphorylation /// negative regulation of protein kinase activity /// signal transduction protein serine/threonine kinase activity /// ATP binding /// transferase activity --- --- ---
1250_at protein kinase, DNA-activated, catalytic polypeptide PRKDC double-strand break repair /// DNA recombination /// protein modification inositol/phosphatidylinositol kinase activity /// protein serine/threonine kinase activity /// transferase activity nucleus Cell_Cycle www.genmapp.org/MAPPSet-Human/KEGG_Pathway_MAPPs/Hs_Cell_Cycle.htm
1258_s_at --- --- --- ERCC4;nucleic acid binding;3.6e-47 --- --- ---
1269_at phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) PIK3R1 SH2;intracellular signaling cascade;2.8e-23 --- --- --- ---
1272_at eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa EIF2S3 protein biosynthesis translation initiation factor activity /// GTP binding /// protein-synthesizing GTPase activity /// GTP_EFTU;translation elongation factor activity;1.5e-35 cytosolic small ribosomal subunit (sensu Eukarya) /// eukaryotic translation initiation factor 2 complex Translation_Factors www.genmapp.org/MAPPSet-Human/GenMAPP.org_MAPPs/Other_MAPPs/Hs_Translation_Factors.htm
1275_at --- --- --- --- --- --- ---
1294_at ubiquitin-activating enzyme E1-like UBE1L ubiquitin cycle ubiquitin activating enzyme activity /// ubiquitin conjugating enzyme activity /// enzyme activator activity /// ligase activity /// ThiF;catalytic activity;3e-49 --- Proteasome_Degradation www.genmapp.org/MAPPSet-Human/GenMAPP.org_MAPPs/Other_MAPPs/Hs_Proteasome_Degradation.htm
1306_at eukaryotic translation initiation factor 4 gamma, 1 EIF4G1 regulation of translation translation factor activity, nucleic acid binding /// MIF4G;RNA binding;2e-57 eukaryotic translation initiation factor 4 complex Translation_Factors www.genmapp.org/MAPPSet-Human/GenMAPP.org_MAPPs/Other_MAPPs/Hs_Translation_Factors.htm
1319_at discoidin domain receptor family, member 2 DDR2 protein amino acid phosphorylation /// cell adhesion /// signal transduction /// transmembrane receptor protein tyrosine kinase signaling pathway transmembrane receptor protein tyrosine kinase activity /// receptor activity /// ATP binding /// transferase activity integral to plasma membrane --- ---
1372_at tumor necrosis factor, alpha-induced protein 6 TNFAIP6 inflammatory response /// cell adhesion /// signal transduction /// cell-cell signaling cell adhesion receptor activity /// hyaluronic acid binding extracellular --- ---
1385_at transforming growth factor, beta-induced, 68kDa TGFBI Fasciclin;cell adhesion;1.1e-11 --- --- --- ---
1388_g_at vitamin D (1,25- dihydroxyvitamin D3) receptor VDR regulation of transcription, DNA-dependent /// signal transduction transcription factor activity /// steroid hormone receptor activity /// vitamin D3 receptor activity nucleus Nuclear_Receptors /// Ovarian_Infertility_Genes www.genmapp.org/MAPPSet-Human/GenMAPP.org_MAPPs/Gene_Family_MAPPs/Hs_Nuclear_Receptors.htm /// www.genmapp.org/MAPPSet-Human/GenMAPP.org_MAPPs/Other_MAPPs/Hs_Ovarian_Infertility_Genes.htm

Total number of rows: 3329

Table truncated, full table size 657 Kbytes.




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