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| Status |
Public on Aug 19, 2020 |
| Title |
Genome-wide microRNAs analysis of peripheral blood mononuclear cells reveals elevated miR-142-3p expression as a potential biomarker for secondary syphilis |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Treponema pallidum subspecies pallidum (T. pallidum) infection induces significant immune responses, resulting in tissue damage. Gene expression plays an essential role in regulating the progression of syphilis infection. However, little is known about the regulatory role of miRNAs in the immune response to T. pallidum infection. Here, we analyze the differential expression of miRNAs in peripheral blood mononuclear cells (PBMCs) between secondary syphilis (SS) patients and healthy controls and study the correlation between miRNAs expression and clinical features with bioinformatics.
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| Overall design |
RNA extraction and Affymetrix microarray analysis were performed on peripheral blood mononuclear cells from healthy and secondary syphilis patients. In order to reduce the interference factors caused by treatment, we selected syphilis subjects who had not been treated before the collection of specimens. To this end, we compared the differential expression of miRNAs in peripheral blood mononuclear cells of healthy and secondary syphilis patients.
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| Contributor(s) |
Yang Z, Liu W, Si C, Yuan L, Yang X, Gan Z |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 18, 2020 |
| Last update date |
Aug 21, 2020 |
| Contact name |
sheng zhu yang |
| E-mail(s) |
supersi@aliyun.com
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| Organization name |
Beijing Tongren Hospital
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| Street address |
No. 1 Dongjiaomin Lane, Dong Cheng District
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| City |
Beijing |
| ZIP/Postal code |
100730 |
| Country |
China |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (12)
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| GSM4730445 |
peripheral blood mononuclear cells at secondary syphilis patient, biological rep1 |
| GSM4730446 |
peripheral blood mononuclear cells at secondary syphilis patient, biological rep2 |
| GSM4730447 |
peripheral blood mononuclear cells at secondary syphilis patient, biological rep3 |
| GSM4730448 |
peripheral blood mononuclear cells at secondary syphilis patient, biological rep4 |
| GSM4730449 |
peripheral blood mononuclear cells at secondary syphilis patient, biological rep5 |
| GSM4730450 |
peripheral blood mononuclear cells at secondary syphilis patient, biological rep6 |
| GSM4730451 |
peripheral blood mononuclear cells at healthy subject, biological rep1 |
| GSM4730452 |
peripheral blood mononuclear cells at healthy subject, biological rep2 |
| GSM4730453 |
peripheral blood mononuclear cells at healthy subject, biological rep3 |
| GSM4730454 |
peripheral blood mononuclear cells at healthy subject, biological rep4 |
| GSM4730455 |
peripheral blood mononuclear cells at healthy subject, biological rep5 |
| GSM4730456 |
peripheral blood mononuclear cells at healthy subject, biological rep6 |
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| Relations |
| BioProject |
PRJNA657862 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE156421_RAW.tar |
9.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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