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| Status |
Public on Aug 25, 2020 |
| Title |
Gene expression profilings of naive B cell, memory B cell and plasmablast of healthy donors and SLE patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of various pathogenic autoantibodies. Increased type I interferon signature is suggested as a trigger of the disease. Previous studies identify increased plasmablasts in peripheral blood of SLE patients. In spite of the unique cellular properties of the plasmablasts compared with other B cell subsets and plasma cells, the biological characteristics of SLE plasmblast remain unknown and few therapeutic strategies targeting SLE plasmablasts have been applicated. We performed microarray analysis of naive, memory B cells and plasmablasts (CD38+CD43+ B cells) freshly isolated from healthy controls and active SLE (n=4, each) to find the unique biological properties of SLE plasmablast.
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| Overall design |
Naive B cell, memory B cell and plasmablast were isolated from freshly separated peripheral blood mononuclear cell derived from 4 healthy donors and 4 systemic lupus erythematosus patients
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| Contributor(s) |
Fujii H, Akita K |
| Citation(s) |
33633721 |
| Submission date |
Aug 24, 2020 |
| Last update date |
Mar 02, 2021 |
| Contact name |
Hiroshi Fujii |
| E-mail(s) |
hf460715@icloud.com
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| Organization name |
Tohoku University, School of Medicine
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| Department |
Department of Hematotology and Rheumatology
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| Street address |
Seiryo 1-1, Aoba-ku
|
| City |
Sendai |
| State/province |
MIyagi |
| ZIP/Postal code |
980-8574 |
| Country |
Japan |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA658971 |
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