|
| Status |
Public on Sep 04, 2020 |
| Title |
ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [single cell RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the effects of ERG on prostate tumorigenesis, ERG-mediated oncogene addiction, and downstream AR signaling pathways. We determined that ERG facilitates AR-signaling and mediates transformation of prostate cells by maintaining coregulator complex formation at AR-bound sites across the genome.
|
| |
|
| Overall design |
We measured changes in multiple chromatin, transcription factor binding, and transcriptomic profiles from genetic alterations of Pten and ERG murine prostate organoids
|
| |
|
| Contributor(s) |
Brown M, Shah N, Kesten N |
| Citation(s) |
32934023 |
| Submission date |
Sep 03, 2020 |
| Last update date |
Dec 04, 2020 |
| Contact name |
Neel Shah |
| E-mail(s) |
neel_shah@dfci.harvard.edu
|
| Organization name |
Dana-Farber Cancer Institute
|
| Street address |
450 Brookline Ave
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE157413 |
ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer |
|
| Relations |
| BioProject |
PRJNA661235 |
| SRA |
SRP279957 |
Less...
More...