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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 24, 2020 |
| Title |
Cyclodextrin-derived Nano-medicine Suppresses the Progression of Colorectal Cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The malignancy of colorectal cancer is connected with inflammation, which poses great therapeutic challenges. To integratetherapeutic targets with anti-inflammation strategy, wedeveloped a biocompatible, non-covalent channel-type nanoparticles that was fabricated through host-guest complexation and multiple assemble of mannose-modified ?-cyclodextrin (M-?-CD) with Regorafenib (RG), denoted as RG@M-?-CD. For in vivo application, the channel-type formulation optimized the pharmacokinetics and bio-distribution of RG. In colitis-associated cancer (CAC) and CT26 models, RG@M-?-CD was proven to be a targeted, safe and effective anti-tumor nanomedicine that suppressed tumor cells proliferation, lesioned neovascularization, and attanuated inflammation. To investigate the therapeutic mechanism of RG@M-?-CD nanomedicine, small pieces of colon tissue with tumors from control group and treatment group were used to perform the microarray for gene expression anaylsis.
The RGnanomedicine is constructed through the host-guest assemble between mannose-modified ?-cyclodextrin (M-?-CD) and TKI Regorafenib (RG). With multiple assemble, the host-guest system is transformed into nanoparticle, denoted as RG@M-?-CD (or RG nanomedicine).
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| Overall design |
Colitis-associated colon cancer model is established using AOM-DSS in C57 mice. The CAC mice are then treated with Rgnanomedicine or PBS.
After treatment, the tumor loading colon tissues are selected to perform the mRNA expression evaluation.
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| Contributor(s) |
Zhou J, Bai HZ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 15, 2020 |
| Last update date |
Sep 27, 2020 |
| Contact name |
Harrison Bai |
| E-mail(s) |
leslie306@126.com
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| Organization name |
Zhejiang University
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| Street address |
Tianmu Road 148#
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| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310000 |
| Country |
China |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA665242 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE157993_RAW.tar |
86.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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