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Series GSE158063 Query DataSets for GSE158063
Status Public on Sep 16, 2020
Title Smaller stature in childhood following assisted reproductive technologies (ART) is not explained by parental or gestational factors, early childhood environment, or fetal DNA methylation [GUSTO_buffy_coat]
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary As part of an investigation on contributors to offspring size following assisted reproduction, we investigated maternal mid-/late-pregnancy peripheral blood buffy coat DNA methylation at 240 CpGs previously associated with maternal pregnancy morbidity or offspring growth across various tissues. Illumina Infinium MethylationEPIC BeadChip was used to obtain DNA methylation profiles in previously frozen buffy coat samples from 70 women who conceived via assisted reproduction technologies and gave live births and 845 women who spotaneously conceived and gave live births.
 
Overall design GUSTO (Growing Up In Singapore Towards healthy Outcomes; n = 1178) is a nationally-representative pregnancy and birth cohort with continuous follow-up from early gestiation through 10 years. Illumina Infinium MethylationEPIC BeadChip was used to evaluate genome-wide DNA methylation in maternal peripheral blood buffy coat in mid-/late- pregnancy (~26-28 gestational weeks) for all subjects with sufficient sample quantities. Genome-wide DNA methylation in fetal cord tissue was profiled separately by Illumina HumanMethylation 450K for all live births with sufficient sample quantities. These data are reported in a a separate series.
 
Contributor(s) Huang J
Citation(s) 34556649
Submission date Sep 16, 2020
Last update date Oct 27, 2021
Contact name Jonathan Yinhao Huang
E-mail(s) jonathan_huang@sics.a-star.edu.sg
Phone +65 6407 0688
Organization name Singapore Institute for Clinical Sciences
Street address 30 Medical Drive
City Singapore
State/province « choose one »
ZIP/Postal code 117609
Country Singapore
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (915)
GSM4787785 peripheral blood buffy coat, S0001
GSM4787786 peripheral blood buffy coat, S0003
GSM4787787 peripheral blood buffy coat, S0004
This SubSeries is part of SuperSeries:
GSE158064 Smaller stature in childhood following assisted reproductive technologies (ART) is not explained by parental or gestational factors, early childhood environment, or fetal DNA methylation
Relations
BioProject PRJNA663879

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE158063_RAW.tar 12.8 Gb (http)(custom) TAR (of IDAT)
GSE158063_chr1-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 104.7 Mb (ftp)(http) TXT
GSE158063_chr10-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 55.5 Mb (ftp)(http) TXT
GSE158063_chr11-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 65.3 Mb (ftp)(http) TXT
GSE158063_chr12-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 57.4 Mb (ftp)(http) TXT
GSE158063_chr13-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 27.6 Mb (ftp)(http) TXT
GSE158063_chr14-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 38.2 Mb (ftp)(http) TXT
GSE158063_chr15-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 37.0 Mb (ftp)(http) TXT
GSE158063_chr16-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 48.9 Mb (ftp)(http) TXT
GSE158063_chr17-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 56.4 Mb (ftp)(http) TXT
GSE158063_chr18-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 20.5 Mb (ftp)(http) TXT
GSE158063_chr19-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 47.5 Mb (ftp)(http) TXT
GSE158063_chr2-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 84.5 Mb (ftp)(http) TXT
GSE158063_chr20-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 32.9 Mb (ftp)(http) TXT
GSE158063_chr21-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 14.3 Mb (ftp)(http) TXT
GSE158063_chr22-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 24.8 Mb (ftp)(http) TXT
GSE158063_chr3-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 63.5 Mb (ftp)(http) TXT
GSE158063_chr4-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 47.8 Mb (ftp)(http) TXT
GSE158063_chr5-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 60.1 Mb (ftp)(http) TXT
GSE158063_chr6-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 66.8 Mb (ftp)(http) TXT
GSE158063_chr7-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 59.5 Mb (ftp)(http) TXT
GSE158063_chr8-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 51.5 Mb (ftp)(http) TXT
GSE158063_chr9-v10Residuals_GUSTO_MB_Celltype_Adjusted_Residuals-915samples.txt.gz 32.3 Mb (ftp)(http) TXT
Processed data are available on Series record

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