|
| Status |
Public on Mar 01, 2022 |
| Title |
Cmarr/miR-540-3p axis promotes cardiomyocyte maturation transition by orchestrating Dtna expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Here, our study showed that a heart-rich lncRNA, Cmarr, which is specifically upregulated during heart development, promoted the maturation transition of ESC-CMs. Cmarr interacted with miR-540-3p to increase the expression of Dtna (a key component of DGC), thus served as a new regulator of the DGC-YAP complex and cardiomyocyte maturation. Our study further identified that Cmarr could recover Dtna expression in the MI heart and attenuate the cardiac remodeling.
|
| |
|
| Overall design |
RNA-seq and miRNA-seq of heart tissues
|
| |
|
| Contributor(s) |
Wu Y, Guo X |
| Citation(s) |
36035750 |
| Submission date |
Sep 18, 2020 |
| Last update date |
Aug 31, 2022 |
| Contact name |
Yukang Wu |
| E-mail(s) |
yukang_wu@tongji.edu.cn
|
| Organization name |
tongji university
|
| Street address |
siping road 1239
|
| City |
shanghai |
| ZIP/Postal code |
20092 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA664356 |
| SRA |
SRP283452 |
Less...
More...