|
| Status |
Public on Nov 14, 2020 |
| Title |
DUSP11-mediated Control of 5’-Triphosphate RNA Regulates RIG-I Sensitivity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Mice lacking DUSP11 display enhanced interferon signaling signature
|
| |
|
| Overall design |
RNA extracted from liver (n=24) or spleen (n=6) of wild-type (n=15) and DUSP11-deficient (n=15) mice subjected to immune-stimulatory 5'-ppp RNA treatment (n=12 liver, 8 male/4 female), mock treatment (n=6 liver, 2 male/4 female; n=6 spleen, 2 male/4 female), or untreated (n=6 liver, 4 male/2 female). Mice were age/sex pair-matched within each treatment.
|
| |
|
| Contributor(s) |
Choi JH, Burke JM, Szymanik KH, Nepal U, Battenhouse A, Lau JT, Stark A, Lam V, Sullivan CS |
| Citation(s) |
33184222 |
| Submission date |
Sep 30, 2020 |
| Last update date |
Feb 13, 2021 |
| Contact name |
Anna Battenhouse |
| Organization name |
The University of Texas at Austin
|
| Department |
Center for Biomedical Research Support
|
| Lab |
Bioinformatics Consulting Group
|
| Street address |
100 East 24th St., Stop A5000
|
| City |
Austin |
| State/province |
TX |
| ZIP/Postal code |
78712 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (30)
|
|
| Relations |
| BioProject |
PRJNA666674 |
| SRA |
SRP285938 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE158837_DESeq2.liver.all.5pppRNA_Treatment_vs_Mock_Unstimulated.results.tsv.gz |
15.8 Mb |
(ftp)(http) |
TSV |
| GSE158837_DESeq2.liver.mock_none.Dusp11_Deficient_vs_WT.results.tsv.gz |
9.1 Mb |
(ftp)(http) |
TSV |
| GSE158837_DESeq2.liver.mock_none.Txf_Mock_vs_None.results.tsv.gz |
9.1 Mb |
(ftp)(http) |
TSV |
| GSE158837_DESeq2.liver.mock_only.Dusp11_Deficient_vs_WT.results.tsv.gz |
8.7 Mb |
(ftp)(http) |
TSV |
| GSE158837_DESeq2.liver.notxf_only.Dusp11_Deficient_vs_WT.results.tsv.gz |
5.4 Mb |
(ftp)(http) |
TSV |
| GSE158837_DESeq2.liver.stim_only.Dusp11_Deficient_vs_WT.results.tsv.gz |
5.3 Mb |
(ftp)(http) |
TSV |
| GSE158837_DESeq2.spleen.all.Dusp11_Deficient_vs_WT.results.tsv.gz |
6.4 Mb |
(ftp)(http) |
TSV |
| GSE158837_RAW.tar |
52.8 Mb |
(http)(custom) |
TAR (of TSV) |
| GSE158837_aa_GEO_Supplemental_data_descriptions.xlsx |
21.0 Kb |
(ftp)(http) |
XLSX |
| GSE158837_topGO.BP.liver.all.5pppRNA_Treatment_vs_Mock_Unstimulated.maxQ.0.1.lfc.up.0.5.filt_padj.tsv.gz |
735.0 Kb |
(ftp)(http) |
TSV |
| GSE158837_topGO.BP.liver.mock_none.Dusp11_Deficient_vs_WT.maxQ.0.1.lfc.up.0.5.filt_padj.tsv.gz |
42.0 Kb |
(ftp)(http) |
TSV |
| GSE158837_topGO.BP.liver.mock_none.Txf_Mock_vs_None.counts.maxQ.0.1.lfc.down.-0.5.filt_padj.tsv.gz |
1.3 Mb |
(ftp)(http) |
TSV |
| GSE158837_topGO.BP.liver.mock_none.Txf_Mock_vs_None.counts.maxQ.0.1.lfc.up.0.5.filt_padj.tsv.gz |
1.3 Mb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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