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| Status |
Public on Jan 20, 2021 |
| Title |
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Microarray Dataset 3] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
An interplay between immune signals, isoprenoids-mediated protein prenylation, and intracellular signaling for the differentiation and maintenance of eTreg cells.
We used microarrays to compare the global transcription profiles of in vitro activated CD4+YFP+CD44loCD62Lhi cTreg cells sorted from Foxp3YFP-Cre mice and activated by 10 ug/ml anti-CD3/28 antibodies plus 200 U/ml IL-2 for different time points in the presence of prenylation inhibitors
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| Overall design |
In total 20 samples were analyzed: DMSO at 0 h (n=3), DMSO at 18 h (n=3), FTI at 18 h (n=3), GGTI at 18 h (n=2), DMSO at 48 h (n=3), FTI at 48 h (n=3), GGTI at 48 h (n=3)
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| Contributor(s) |
Su W, Shi H, Dhungana Y, Chi H |
| Citation(s) |
33207246 |
| Submission date |
Oct 01, 2020 |
| Last update date |
Jan 24, 2021 |
| Contact name |
Hongbo Chi |
| E-mail(s) |
hongbo.chi@stjude.org
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| Organization name |
St Jude Children's Research Hospital
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| Department |
Immunology
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| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE158863 |
Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells |
|
| Relations |
| BioProject |
PRJNA666785 |
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