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| Status |
Public on Nov 17, 2020 |
| Title |
Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy (Exome) |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by high throughput sequencing
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| Summary |
Purpose: There are three goals of this study: 1. To compare the genomic, exome and chromatin accessiblity profiles of the specific engineered fallopian tube cells of high-grade serous tubo-ovarian cancer (HGSC) models (this study) using whole-exome, whole-genome and ATAC-seq sequencing.
Methods: For whole-exome analysis, genomic DNA was extracted from the cell lines mentioned below.
Conclusions: We conclude that whole-exome, whole-genome and ATAC-seq characterization would expedite genetic network analyses and permit the dissection of complex biological functions.
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| Overall design |
Genomic profiles from specific engineered fallopian tube cells were generated by whole-exome, whole-genome and ATAC-seq sequencing.
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| Contributor(s) |
Weinberg RA, Iyer S, Bell GW |
| Citation(s) |
33158843 |
| Submission date |
Oct 08, 2020 |
| Last update date |
Nov 17, 2020 |
| Contact name |
Sonia Iyer |
| E-mail(s) |
iyers@wi.mit.edu, ibarrasa@wi.mit.edu, gbell@wi.mit.edu
|
| Organization name |
Whitehead Institute
|
| Lab |
Weinberg
|
| Street address |
455 Main Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
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| Platforms (1) |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE158474 |
Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy |
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| Relations |
| BioProject |
PRJNA668139 |
| SRA |
SRP286773 |
