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Series GSE15940 Query DataSets for GSE15940
Status Public on Feb 08, 2012
Title Sex-Dependent Programming of Glucose and Fatty Acid Metabolism in Mouse Offspring by Maternal Protein Restriction
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis of glucose and Lipid metabolism in male and female offspring after protein restriction of the mother

Male offspring showed features of metabolic syndrome after receiving a high fat diet, regardless of the diet of the dam. Glucose and lipid metabolism in male offspring was unaltered. Insulin sensitivity and hepatic fatty acid storage in female offspring of low-protein-fed dams changed in such a way that it resembled the male pattern of insulin sensitivity and hepatic fatty acid storage. Microarray analysis on hepatic gene expression patterns confirmed these findings. We therefore conclude that in mice, maternal protein restriction does not change the response of glucose and fatty acid metabolism to a high fat diet in male offspring, but does program metabolism in female offspring in such a way that it resembles male metabolism. Our findings might have implications for potential future gender-specific treatment of the features of metabolic diseases.
Overall design Total RNA obtained from liver (16 samples per gender) were compared in the different groups. In total, 4 groups per gender, each group consisting of 4 biological replicates.
Contributor(s) van Straten EM, Bloks VW, Plosch T, van Dijk TH, Baller JF, Huijkman NC, Kuipers I, Verkade H
Citation(s) 22361840
Submission date May 04, 2009
Last update date Jun 14, 2018
Contact name vincent bloks
Organization name UMCG
Department Pediatrics
Lab Pediatrics
Street address Hanzeplein1
City Groningen
ZIP/Postal code 9713GZ
Country Netherlands
Platforms (2)
GPL6103 Illumina mouseRef-8 v1.1 expression beadchip
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (32)
GSM399917 1F-Control 9%
GSM399918 2F-Control 9%
GSM399919 3F-Control 9%
BioProject PRJNA116989

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15940_RAW.tar 6.5 Mb (http)(custom) TAR
GSE15940_non-normalized_female.txt.gz 2.7 Mb (ftp)(http) TXT
GSE15940_non-normalized_male.txt.gz 2.6 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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