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Series GSE1615 Query DataSets for GSE1615
Status Public on Jan 04, 2005
Title Theca cell gene expression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects 5-10% of reproductive aged women. The hallmark characteristic of PCOS is increased ovarian androgen synthesis. Previous studies by our laboratory demonstrated that increased androgen synthesis is a stable biochemical phenotype of PCOS theca cells which are the primary source of ovarian androgen production. The increase in theca cell steroidogenesis was due to an increase in expression of several steroidogenic enzymes including CYP17 and CYP11A but not StAR. Interestingly, the anti-epileptic drug valproic acid induces increased theca cell androgen synthesis and increased CYP17 and CYP11A mRNA levels. In this study we have characterized the gene expression profiles of theca cells obtained from normal or polycystic ovaries which were maintained in the absence (UNT) or presence (VPA) of valproic acid. The data identifed new candidate genes and novel signaling pathways which may contribute to the manifestation of PCOS phenotypes including increased androgen production. The experiments in this study were carried using the Affymetrix U133A and U133B oligonucleotide chips.
Keywords: other
Contributor(s) Wood JR, Nelson-Degrave VL, Jansen E, McAllister JM, Mosselman S, Strauss JF
Citation(s) 15598877
Submission date Jul 27, 2004
Last update date Aug 10, 2018
Contact name Jennifer Rebecca Wood
Phone 215-898-0145
Fax 215-573-5408
Organization name University of Pennsylvania
Department Center for Research on Reproduction and Women's Health
Lab Strauss
Street address 421 Curie Blvd
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
Samples (26)
GSM27531 UNT-NL 1
GSM27532 UNT-NL 2
GSM27533 UNT-NL 3
BioProject PRJNA90717

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Supplementary file Size Download File type/resource
GSE1615_RAW.tar 86.2 Mb (http)(custom) TAR (of CEL, EXP)
Raw data provided as supplementary file

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