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| Status |
Public on Nov 16, 2020 |
| Title |
RNA-sequencing of bulk small cell lung cancer lung tumors generating by either injecting LSL-Cas9 mice with a sgControl RPP CMV Cre adenovirus or a sgKdm5a RPP CMV Cre adenovirus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the RNA-sequencing results from small cell lung cancer lung tumors from lox-stop-lox Cas9 mice that were injected with sgControl RPP CMV Cre adenovirus or sgKdm5a RPP CMV Cre adenovirus. Mice were enrolled in a survival study where at their endpoint, tumors were harvested and subjected to RNA-sequencing analysis. RPP-sgRb1, sgTrp53, sgRbl2. sgControl=C0111
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| |
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| Overall design |
Bulk RNA sequencing from small cell lung cancer lung tumors that are KDM5A mutant (sgKdm5a RPP) or KDM5A WT (sgControl RPP)
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| |
|
| Contributor(s) |
Oser MG, Kaelin WG Jr |
| Citation(s) |
31727771 |
| Submission date |
Nov 16, 2020 |
| Last update date |
Nov 17, 2020 |
| Contact name |
Matthew Oser |
| E-mail(s) |
moser@partners.org
|
| Phone |
9174883166
|
| Organization name |
Dana-Farber Cancer Institute
|
| Street address |
450 Brookline Avenue, Mayer 457
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE161548 |
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis |
|
| Relations |
| BioProject |
PRJNA678625 |
| SRA |
SRP292680 |
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