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| Status |
Public on Oct 01, 2021 |
| Title |
Identification of differentially expressed miRNAs after knockdown of ELF3-AS1 in gastric cancer |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
In this study, we used miRNA sequencing to analyze and identify possible miRNAs that can be regulated by and ELF3-AS1 in gastric cancer. The results showed that lncRNA ELF3-AS1 knockdown decreased the expression of miR-33a/b and miR-203a. Due to miR-33a/b and miR-203a were able to target SNAI2 expression, and ELF3-AS1 knockdown significantly upregulates SNAI2 expression, we speculated ELF3-AS1 may negatively regulate SNAI2 expression through positively regulating the expression of miR-33a/b and miR-203a in GC.
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| Overall design |
To reveal the possible target miRNAs of ELF3-AS1 in gastric cancer, we knocked down the ELF3-AS1 expression in AGS cell lines. The potent differential expressed microRNAs after silencing ELF3-AS1 were identified by microRNA sequencing.
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| Contributor(s) |
Qin S, Li D |
| Citation(s) |
36457025 |
| Submission date |
Nov 16, 2020 |
| Last update date |
Dec 02, 2022 |
| Contact name |
Qin Shanshan |
| E-mail(s) |
qinss77@163.com
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| Organization name |
Institute of Basic Medical Sciences, School of Basic Medical Sciences, Hubei University of Medicine
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| Street address |
Renmin Road 30, Maojian District
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| City |
Shiyan |
| ZIP/Postal code |
442000 |
| Country |
China |
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| Platforms (1) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA678706 |
| SRA |
SRP292732 |
