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| Status |
Public on May 17, 2021 |
| Title |
Characterization of CD44low CD62Llow CD8 T-cell subset |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To characterize CD44low CD62low CD8 T-cell subset (P4), we compared gene expression among four CD8 T-cell subsets. A hierarchical clustering of global gene expression showed that each subset of CD8 T-cells expresses a distinct gene profile. Genes expressed in activated T-cells were highly expressed in P4 cells compared to naive P1 cells. On the other hand, genes expressed in differentiated T-cells were less expressed in P4 cells compared to either central memory (P2) or effector/memory (P3) cells. These results indicate that P4 cells are in an activated, but pre-mature state and distinct from more differentiated subsets of CD8 T-cells such as central memory and effector/memory cells.
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| |
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| Overall design |
FACS sorted CD8 subset cells from spleens and lymph nodes of PD-1-/- C57BL/6 mice
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| |
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| Contributor(s) |
Nakajima Y, Chamoto K, Honjo T |
| Citation(s) |
34088845 |
| Submission date |
Nov 17, 2020 |
| Last update date |
Sep 05, 2021 |
| Contact name |
Kenji Chamoto |
| Organization name |
Graduate School of Medicine, Kyoto University
|
| Department |
Department of Immunology and Genomic Medicine
|
| Street address |
Yoshida Konoe-cho, Sakyo-ku
|
| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
606-8501 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA679044 |
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