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| Status |
Public on Jan 19, 2010 |
| Title |
Bone-marrow derived macrophages response to the Whipple's disease agent, Tropheryma whipplei |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We have employed whole genome microarray expression profiling to identify differently expressed genes following infection of bone-marrow derived macrophages with T. whipplei. Macrophages were infected with T. whipplei (MOI 50:1) for 6 hours and a signature was identified that distinguished between infected and control samples. Expression of several genes from this signature was quantified in the same RNA samples by real-time PCR, confirming the predicted macrophage response pattern.
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| |
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| Overall design |
Gene expression in macrophages was measured at 6 hours after infection. Three independent experiments were performed.
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| |
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| Contributor(s) |
Desnues B |
| Citation(s) |
20090833, 21042409 |
| Submission date |
May 20, 2009 |
| Last update date |
May 10, 2018 |
| Contact name |
Benoit Desnues |
| E-mail(s) |
benoit.desnues@univmed.fr
|
| Organization name |
Faculté de Médecine de la Timone
|
| Department |
URMITE UMR CNRS 6236
|
| Street address |
27 boulevard Jean Moulin
|
| City |
Marseille |
| ZIP/Postal code |
13385 cedex 05 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE20210 |
Role of interleukin-16 in macrophage responses to Tropheryma whipplei and lipopolysaccharide |
|
| Relations |
| BioProject |
PRJNA129025 |
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