|
| Status |
Public on Mar 01, 2021 |
| Title |
Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
to identify transcriptomic biomarker pathways in peripheral blood that are associated with or predict the development of death or fatal C-IRIS among patients with CM who were enrolled in the Cryptococcal Optimal ART Timing (COAT) Trial.
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| |
|
| Overall design |
We assessed peripheral blood gene expression using next-generation RNA sequencing in 4 groups of patients with CM: 1) no C-IRIS or Death; 2) C-IRIS survivors; 3) fatal C-IRIS; 4) Death without C-IRIS. Gene expression was assessed at the time of ART initiation, at 1, 4, and 8 weeks on ART, and at the time of C-IRIS events.
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| |
|
| Contributor(s) |
Vlasova-St. Louis I |
| Citation(s) |
33863324 |
| Submission date |
Dec 09, 2020 |
| Last update date |
Jun 07, 2021 |
| Contact name |
Irina Vlasova-St. Louis |
| E-mail(s) |
irinastl@umn.edu
|
| Organization name |
University of Minnesota
|
| Department |
Medicine
|
| Street address |
2001 6th St SE
|
| City |
Minnespolis |
| State/province |
MN |
| ZIP/Postal code |
55455 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (211)
|
|
| Relations |
| BioProject |
PRJNA683803 |
| SRA |
SRP297342 |
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