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| Status |
Public on Dec 12, 2020 |
| Title |
Expression profile of 58As9 cells upon PLEKHA5 knockdown |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Phosphoproteomic analysis of diffuse-type gastric carcinoma cells with Met gene amplification identified Pleckstrin Homology Domain Containing A5 (PLEKHA5) as a protein that is tyrosine-phosphorylated downstream of Met.
We used DNA microarray analysis to explore the signaling pathways downstream of PLEKHA5 that regulates the survival and peritoneal dissemination of Met-amplified 58As9 diffuse-type gastric carcinoma cells.
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| Overall design |
58As9 cells were transfected with conrol or PLEKHA5 siRNA for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Nagamura Y, Miyazaki M, Nagano Y, Yuki M, Fukami K, Yanagihara K, Sasaki K, Sakai R, Yamaguchi H |
| Citation(s) |
33677467 |
| Submission date |
Dec 11, 2020 |
| Last update date |
Mar 14, 2021 |
| Contact name |
Hideki Yamaguchi |
| E-mail(s) |
hidyamag.si@gmail.com
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| Organization name |
Sasaki Institute
|
| Department |
Cancer Cell Research
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| Street address |
2-2, KANDASURUGADAI, CHIYODA-KU
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| City |
TOKYO |
| ZIP/Postal code |
101-0062 |
| Country |
Japan |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA684583 |
