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| Status |
Public on Oct 11, 2021 |
| Title |
Chromatin accessibility regions in GC B cells during acute and chronic viral infection |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
To study how chronic viral infection disrupts B cell differentiation pathways and identify key intrinsic regulators in an endogenous polyclonal response, we used the comparative LCMV model. Wild-type mice were infected with either the acute (WE) versus chronic (Docile) strains of LCMV, GC B cells (CD19+IgDloCD95+CD38loCD138-) isolated 14 days post-infection, an ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) was undertaken.
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| |
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| Overall design |
8 samples. Each group has at least 4 biological replicates.
|
| Web link |
https://0-doi-org.brum.beds.ac.uk/10.1038/s41590-021-01077-y
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| |
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| Contributor(s) |
Di Pietro A, Good-Jacobson K, Scharer CD, Mi T |
| Citation(s) |
34845392 |
| Submission date |
Dec 16, 2020 |
| Last update date |
Jan 19, 2022 |
| Contact name |
Andrea Di Pietro |
| E-mail(s) |
dipi.andrea@gmail.com
|
| Phone |
+610450240751
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| Organization name |
Monash University
|
| Department |
Biochemistry and Molecular Biology
|
| Lab |
B cells, Antibody, Memory Laboratory
|
| Street address |
15 Innovation Walk, Monash University
|
| City |
Clayton |
| State/province |
VIC |
| ZIP/Postal code |
3800 |
| Country |
Australia |
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| Platforms (1) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE163365 |
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection |
|
| Relations |
| BioProject |
PRJNA685825 |
| SRA |
SRP298208 |
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