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| Status |
Public on Jan 14, 2021 |
| Title |
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The p53 inhibitor MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML). Utilizing hematopoietic stem cells from four non-leukemic/pre-leukemic murine models, we performed bulk transcriptomic analysis to evaluate the impact of Mdmx overexpression.
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| Overall design |
Flk2- Lin-Sca-1+Kit+ (LSK) cells were sorted from the bone marrow of wild-type, Mdmx-Tg, Pu.1-URE-/-, Mdmx-Tg/Pu.1-URE-/- murine models. Three replicates were sequenced for each cohort.
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| Contributor(s) |
Ueda K, Kumari R, Schwenger E, Wheat JC, Bohorquez O, Rao Narayanagari S, Taylor SJ, Carvajal LA, Pradhan K, Bartholdy B, Todorova TI, Goto H, Sun D, Chen J, Shan J, Song Y, Montagna C, Xiong S, Lozano G, Pellagatti A, Boultwood J, Verma A, Steidl U |
| Citation(s) |
33667384 |
| Submission date |
Jan 14, 2021 |
| Last update date |
Apr 15, 2021 |
| Contact name |
Ulrich Steidl |
| E-mail(s) |
ulrich.steidl@einsteinmed.org
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| Organization name |
Albert Einstein College of Medicine
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| Street address |
1300 Morris Park Ave.
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| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
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| Platforms (1) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA692186 |
| SRA |
SRP301763 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE164838_RAW.tar |
18.3 Mb |
(http)(custom) |
TAR (of SF) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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