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| Status |
Public on May 25, 2021 |
| Title |
Distinct transcriptional profile of blood mononuclear cells in Behcet’s disease: insights into the central role of neutrophil chemotaxis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Both innate and adaptive immune responses are reportedly increased in Behcet’s disease (BD), a chronic-relapsing systemic vasculitis lying at the intersection between autoinflammation and autoimmunity. To further study pathophysiologic molecular mechanisms operating in BD we searched for transcriptome-wide changes in blood mononuclear cells from these patients. We performed 3’ mRNA next generation sequencing-based genome-wide transcriptional profiling followed by analysis of differential expression signatures, KEGG pathways, GO biological processes and transcription factor signatures al 25 samples (11 healthy controls and 14 BD).
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| Overall design |
25 human samples out of with 11 healthy controls and 14 with Behcet’s disease
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| Contributor(s) |
Verrou K, Vlachogiannis NI, Ampatziadis-Michailidis G, Moulos P, Pavlopoulos GA, Hatzis P, Kollias G, Sfikakis PP |
| Citation(s) |
33493315 |
| Submission date |
Jan 21, 2021 |
| Last update date |
May 25, 2021 |
| Contact name |
Maria G. Tektonidou |
| E-mail(s) |
mtektonidou@gmail.com
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| Organization name |
National and Kapodistrian University of Athens
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| Street address |
Mikras Asias 75
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| City |
Athens |
| State/province |
Please choose a State |
| ZIP/Postal code |
11527 |
| Country |
Greece |
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| Platforms (1) |
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| Samples (25)
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| Relations |
| BioProject |
PRJNA693819 |
| SRA |
SRP302704 |
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