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| Status |
Public on Dec 01, 2009 |
| Title |
Gene expression profiling of NCAM-deficient mouse brain |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of brains of mice lacking the neural cell adhesion molecule NCAM (Ncam-/-) in comparison to wild-type mice of same age and genetic background (Ncam+/+). NCAM-deficient mice exhibit deficits in long-term potentiation and spatial learning, as well as increased intermale aggression.
We performed a microarray analysis of adult NCAM-deficient mouse brains to identify molecular targets which might underly the phenotype of NCAM-deficient mice.
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| Overall design |
We analyzed the gene expression profiles in 2-3 months old (young adult) mouse brains, with both the Ncam-/- and the Ncam+/+ group consisting of three individuals each. Wild-type and NCAM-deficient animals had the same genetic background. RNA was prepared from total brain.
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| Contributor(s) |
Wong YW, Streichert T |
| Citation(s) |
20110269 |
| Submission date |
Jun 16, 2009 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Thomas Streichert |
| Organization name |
University Medical Center Hamburg-Eppendorf
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| Department |
Institute For Clinical Chemistry / Central Laboratories
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| Street address |
Martinistr. 52, Campus Forschung N27, 2. OG
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| City |
Hamburg |
| ZIP/Postal code |
D-20246 |
| Country |
Germany |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA116231 |
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