 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Feb 11, 2021 |
| Title |
Inhibition of xCT Suppresses Melanoma progress |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Tumor cells increase glutamate release through the cystine/glutamate transporter xCT to balance oxidative homeostasis in tumor cells and promote tumor progression. Here, we demonstrated that although inhibition of xCT either by pharmacological inhibitor (sulfasalazine, SAS), approved by FDA for inflammatory diseases, or genetic knockdown induced ROS-related death in melanoma cells. Taken together, our results reveal that inhibition of xCT by SAS is a promising therapeutic strategy for melanoma.
|
| |
|
| Overall design |
mRNA profiles of 3 replicated vehicle and 3 replicated 500μm SAS-treated B16F10 melanoma cells for 24 hours
|
| Web link |
https://pubmed.ncbi.nlm.nih.gov/33744468/
|
| |
|
| Contributor(s) |
liu N, Zhang J, Yin M, Liu H, Zhang X, Li J, Yan B, Guo Y, Zhou J, Tao J, Hu S, Chen X, Peng C |
| Citation(s) |
33744468 |
| Submission date |
Feb 10, 2021 |
| Last update date |
Feb 23, 2023 |
| Contact name |
Nian Liu |
| E-mail(s) |
liunianwc@csu.edu.cn
|
| Phone |
15211126886
|
| Organization name |
Xiangya Hospital, Central South University
|
| Department |
Department of Dermatology
|
| Street address |
Xiangya road 87#
|
| City |
Changsha |
| State/province |
Hunan |
| ZIP/Postal code |
410000 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA701281 |
| SRA |
SRP305712 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE166566_All_samples.GeneExpression.FPKM.xls.gz |
195.9 Kb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...