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Series GSE167219 Query DataSets for GSE167219
Status Public on Jun 02, 2021
Title Expression data from CD73 positive adipose derived mesenchymal stem cells (CD73+ AD-MSCs) and CD73 negative adipose derived mesenchymal stem cells (CD73- AD-MSCs) of mouse
Organism Mus musculus
Experiment type Expression profiling by array
Summary MSCs are a heterogeneous population and the specific population of MSCs may exhibit a selective ability for tissue repair. The aim of our research was to adapt the CD73+ subgroup of adipose derived MSCs (AD-MSCs) for the therapy of myocardial infarction (MI). Our results revealed that CD73+ AD-MSCs played more effective role in the acceleration function of cardiac recovery by promoting angiogenesis in a rat model of MI compared to mixed AD-MSCs and CD73- AD-MSCs.
Microarray analysis shows differences between CD73+ and CD73- AD-MSCs when transcription profile of these two subgroups were compared, especially in VEGF pathway.
 
Overall design AD-MSCs were isolated from adipose tissues surrounding the groin of mice and CD73+ AD-MSCs and CD73- AD-MSCs were sorted using flow cytometry. To investigate the therapeutic effects of CD73+ AD-MSCs, CD73+ AD-MSCs were transplanted into rat model of MI, and CD73- AD-MSCs, normal AD-MSCs transplantation served as control. Microarray analysis detected differences between CD73+ and CD73- AD-MSCs.
 
Contributor(s) Li Q, Hou H
Citation(s) 34055772
Submission date Feb 22, 2021
Last update date Jun 02, 2021
Contact name Huifang Hou
E-mail(s) liangshuang1979@xxmu.edu.cn
Phone +86 18637359227
Organization name Xinxiang Medical University
Street address 601 Jinsui Avenue
City Xinxiang
ZIP/Postal code 453003
Country China
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM5099788 CD73- AD-MSCs of mice rep1
GSM5099789 CD73- AD-MSCs of mice rep2
GSM5099790 CD73- AD-MSCs of mice rep3
Relations
BioProject PRJNA703950

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Supplementary file Size Download File type/resource
GSE167219_RAW.tar 20.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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