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Series GSE16792 Query DataSets for GSE16792
Status Public on Sep 16, 2010
Title Temporal changes of gene expression in rat kidney and lung, and the effect of prior growth inhibition on these changes
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Temporal changes of gene expression from 1-wk- to 5-wk-old rat in kidney and lung, and the effect of prior growth inhibition on these genetic changes.
In mammals, body growth is rapid in early life but decelerates with age. Somatic growth deceleration is caused by a gradual decline in cell proliferation that occurs simultaneously in many different organs, but is not caused by a hormonal mechanism. We hypothesize that growth deceleration is driven by a postnatal genetic program that occurs coordinately in multiple organs.
Using microarrays, we investigated the changes of gene expression that occur with age in kidney and lung as growth slows down, and also investigated whether these changes were growth-driven, by asking whether prior delay of postnatal growth caused by malnutrition (tryptophan deficiency) would also delay these genetic changes.
 
Overall design To compare gene expression between fast-growing animals and more slowly growing animals, we extracted total mRNA from kidney and lung in 1-wk-old and 5-wk-old mice (5 animals each). Then, to investigate the effect of prior growth on these genetic changes, we also extracted total mRNA from kidney and lung in 5-wk-old mice that received a tryptophan-deficient diet from birth to 4wk of age.
 
Contributor(s) Lui JC, Chen W, Baron J
Citation(s) 20371622
Submission date Jun 24, 2009
Last update date Jul 31, 2017
Contact name Julian CK Lui
E-mail(s) luichunk@mail.nih.gov
Phone 301-496-8049
Organization name NICHD, NIH
Lab Section on Growth and Development
Street address 10 Center Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (30)
GSM594728 Rat_Kidney_1wk_biological rep1
GSM594729 Rat_Kidney_1wk_biological rep2
GSM594730 Rat_Kidney_1wk_biological rep3
Relations
BioProject PRJNA117551

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16792_RAW.tar 138.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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