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Series GSE168933 Query DataSets for GSE168933
Status Public on Jan 31, 2022
Title Liver Stromal Cells Restrict Macrophage Maturation and Stromal IL-6 Limits the Differentiation of Cirrhosis-linked Macrophages
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Liver disease is the cause of approximately two million deaths globally per year, yet effective therapies are lacking. Iterative tissue injury leads to prolonged inflammation, extensive fibrosis, and the possible progression to deadly chronic-end stage disease, such as cirrhosis and hepatocellular carcinoma (HCC). In this study we investigated the ability of liver stromal cells to effect macrophage maturation and differentiation by using an in vitro human stromal-myeloid coculture systems and single cell RNA sequencing.
 
Overall design Human liver tissue were disaggregated and profiled using the Chromium Single Cell 3’ Library and Gel Bead Kit v2 (10X Genomics) .
In vitro human stromal-myeloid coculture systems
 
Contributor(s) Mei S
Citation(s) 35074474
Submission date Mar 15, 2021
Last update date Aug 25, 2022
Contact name Shenglin Mei
E-mail(s) samleomei@gmail.com
Organization name Harvard medical school (DMBI)
Street address 10 Shattuck Street
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (95)
GSM5172568 liver, S1
GSM5172569 liver, S2
GSM5172570 liver, S3
Relations
BioProject PRJNA714623

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE168933_RAW.tar 52.4 Mb (http)(custom) TAR (of CSV)
GSE168933_normalized_countstable.csv.gz 8.9 Mb (ftp)(http) CSV
GSE168933_raw_countstable.csv.gz 2.1 Mb (ftp)(http) CSV
SRA Run SelectorHelp
Processed data provided as supplementary file
Processed data are available on Series record
Raw data are available in SRA
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