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| Status |
Public on Nov 17, 2009 |
| Title |
Detection of Treatment-Induced Changes in Signaling Pathways in GI Stromal Tumors using Transcriptomic Data |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Time series data from the GIST-T1 imatinib responsive cell line treated with imatinib mesylate for 0 - 48 hours. The goal of this study was the development of methods to deduce global changes in cell signaling during treatment with targeted therapeutics.
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| Overall design |
26 samples, triplicate measurements at 0, 2, 4, 6, 9, 12, 18, and 48 hrs of 10 microM IM treatment of GIST-T1 cells, duplicate measurements at 24 hr
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| Contributor(s) |
Ochs MF, Rink L, Godwin AK |
| Citation(s) |
19903850, 23694699 |
| Submission date |
Jul 08, 2009 |
| Last update date |
Sep 11, 2019 |
| Contact name |
Michael F Ochs |
| Organization name |
Johns Hopkins University
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| Department |
Oncology Biostatistics
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| Street address |
550 North Broadway, Ste 1103
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (26)
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| GSM425708 |
GIST-T1 cells without IM, First Replicate |
| GSM425709 |
GIST-T1 cells without IM, Second Replicate |
| GSM425710 |
GIST-T1 cells without IM, Third Replicate |
| GSM425711 |
GIST-T1 cells treated with 10 microM IM for 2 hours, First Replicate |
| GSM425712 |
GIST-T1 cells treated with 10 microM IM for 2 hours, Second Replicate |
| GSM425713 |
GIST-T1 cells treated with 10 microM IM for 2 hours, Third Replicate |
| GSM425714 |
GIST-T1 cells treated with 10 microM IM for 4 hours, First Replicate |
| GSM425715 |
GIST-T1 cells treated with 10 microM IM for 4 hours, Second Replicate |
| GSM425716 |
GIST-T1 cells treated with 10 microM IM for 4 hours, Third Replicate |
| GSM425717 |
GIST-T1 cells treated with 10 microM IM for 6 hours, First Replicate |
| GSM425718 |
GIST-T1 cells treated with 10 microM IM for 6 hours, Second Replicate |
| GSM425719 |
GIST-T1 cells treated with 10 microM IM for 6 hours, Third Replicate |
| GSM425720 |
GIST-T1 cells treated with 10 microM IM for 9 hours, First Replicate |
| GSM425721 |
GIST-T1 cells treated with 10 microM IM for 9 hours, Second Replicate |
| GSM425722 |
GIST-T1 cells treated with 10 microM IM for 9 hours, Third Replicate |
| GSM425723 |
GIST-T1 cells treated with 10 microM IM for 12 hours, First Replicate |
| GSM425724 |
GIST-T1 cells treated with 10 microM IM for 12 hours, Second Replicate |
| GSM425725 |
GIST-T1 cells treated with 10 microM IM for 12 hours, Third Replicate |
| GSM425726 |
GIST-T1 cells treated with 10 microM IM for 18 hours, First Replicate |
| GSM425727 |
GIST-T1 cells treated with 10 microM IM for 18 hours, Second Replicate |
| GSM425728 |
GIST-T1 cells treated with 10 microM IM for 18 hours, Third Replicate |
| GSM425729 |
GIST-T1 cells treated with 10 microM IM for 24 hours, First Replicate |
| GSM425730 |
GIST-T1 cells treated with 10 microM IM for 24 hours, Second Replicate |
| GSM425731 |
GIST-T1 cells treated with 10 microM IM for 48 hours, First Replicate |
| GSM425732 |
GIST-T1 cells treated with 10 microM IM for 48 hours, Second Replicate |
| GSM425733 |
GIST-T1 cells treated with 10 microM IM for 48 hours, Third Replicate |
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| Relations |
| BioProject |
PRJNA117765 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE17018_RAW.tar |
346.4 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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