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| Status |
Public on Apr 02, 2021 |
| Title |
Impact of 6-mercaptopurine on LPS treated primary cultures of enteric nervous system |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Enteric nervous system is involved in the regulation of intestinal inflammation. We developped mouse primary cultures of enteric nervous system to study impact of LPS, as pro-inflammatory mediator, and of the pro-drug 6-mercaptopurine on enteric inflammatory pathways
We used microarrays to detail the global programme of gene expression underlying enteric neuro-inflammation and identified classes of up-regulated genes during this process.
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| Overall design |
Mouse ENS primary cultures were treated with LPS in presence or absence of 6-mercaptopurine. Genome-wide expression analysis was performed using Clariom S microarray
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| Contributor(s) |
Cossais F, Kähler M |
| Citation(s) |
33864170 |
| Submission date |
Apr 01, 2021 |
| Last update date |
Jul 02, 2021 |
| Contact name |
Francois Cossais |
| Organization name |
Kiel University
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| Department |
Institute of Anatomy
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| Lab |
Ag_Neurogastro
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| Street address |
Otto-Hahn-Platz 8
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| City |
Kiel |
| ZIP/Postal code |
24118 |
| Country |
Germany |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA719113 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE171308_RAW.tar |
17.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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