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Status |
Public on Apr 09, 2021 |
Title |
Intrapericardial administration of secretomes from endometrial-derived mesenchymal stromal cells: effects on immune-related genes in a porcine model of myocardial infarction |
Organism |
Sus scrofa |
Experiment type |
Expression profiling by array
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Summary |
Using a porcine model of acute myocardial infarction, we explored the potential effect of secretomes from endometrial-derived mesenchymal stromal cells (endMSCs) and from IFNγ/TNFα-primed endMSCs on immune-related genes in the infarcted tissue.
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Overall design |
Infarcted tissues from pigs administered with placebo (n = 4), secretomes from endometrial mesenchymal stromal cells (S-enMSCs) (n = 4), and secretomes from IFNγ/TNFα-primed endometrial derived mesenchymal stromal cells (S-enMSCs*) were collected at 7 days post-therapy for RNA extraction and Affymetrix microarrays. Differentially gene expression analysis between biogroups were performed and immuno-related genes were determined.
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Contributor(s) |
López Nieto E, García Casado J |
Citation(s) |
35625854 |
Submission date |
Apr 08, 2021 |
Last update date |
Jun 01, 2022 |
Contact name |
Juan Carlos Silla-Castro |
Organization name |
CNIC
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Department |
Bioinformatics
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Street address |
Melchor Fernandez Almagro 3
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City |
Madrid |
ZIP/Postal code |
28029 |
Country |
Spain |
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Platforms (1) |
GPL18699 |
[PorGene-1_1-st] Porcine Gene 1.1 ST Array [transcript (gene) version] |
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Samples (12)
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Relations |
BioProject |
PRJNA720692 |