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| Status |
Public on Jan 10, 2010 |
| Title |
Transcription signature of Multiple Sclerosis in peripheral blood mononuclear cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood.
This data series contains the subset of data used to generate a MS signature comparing female healthy specimens with respect to MS patients
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| Overall design |
Subjects were followed in the outpatients clinic and blood was collected before pregnancy and at the following time points during pregnancy: first trimester (gestational age at sampling 12 weeks), second trimester (24 weeks), and third trimester (36 weeks). Before-pregnancy samples were obtained in a treatment-free period and after anticonceptional drug withdrawal.
Peripheral blood mononuclear cells (PBMCs) obtained from 15 women (8 MS patients and 7 healthy controls) were analyzed by oligonucleotide microarray technology.
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| Contributor(s) |
Gilli F, Lindberg R, Valentino P, Marnetto F, Malucchi S, Sala A, Capobianco M, di Sapio A, Sperli F, Kappos L, Calogero R, Bertolotto A |
| Citation(s) |
20126412 |
| Submission date |
Jul 29, 2009 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Raffaele A Calogero |
| E-mail(s) |
raffaele.calogero@unito.it
|
| Phone |
++39 0116706454
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| Organization name |
University of Torino
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| Department |
Molecular Biotechnology Center
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| Lab |
Bioinformatics and Genomics Unit
|
| Street address |
Via Nizza 52
|
| City |
Torino |
| State/province |
To |
| ZIP/Postal code |
10126 |
| Country |
Italy |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE17449 |
Transcription signature of Multiple Sclerosis |
|
| Relations |
| BioProject |
PRJNA123611 |
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