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Series GSE174257 Query DataSets for GSE174257
Status Public on May 11, 2021
Title Expression data from resting and activated murine T cell as well as murine peripheral T cell lymphomas
Organism Mus musculus
Experiment type Expression profiling by array
Summary Peripheral T-cell lymphomas (PTCLs) represent a significant unmet medical need with dismal clinical outcome.T-cell receptor (TCR) is emerging as a key driver of T lymphocytes transformation. However, the role of chronic TCR activation in lymphomagenesis and in survival of lymphoma cells is still poorly understood. Using an original mouse model, we report here that chronic TCR stimulation drives T-cell lymphomagenesis whereas TCR signaling does not contribute to PTCL survival.
Transcriptome analyses of mouse PTCLs revealed a NK-like reprogramming of PTCL cells with expression of NK receptors (NKRs) and downstream signaling molecules such as Tyrobp and Syk.
 
Overall design 15 samples. 9 mPTCLs generated after transfert of p53KO T cells into syngeneic recipient C57BL/6 CD3KO mice and 6 control T cells (3 repetitions of resting T cells and 3 repetitions of in vitro activated p53KO T cells)
 
Contributor(s) Carras S, Bachy E, Genestier L
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Submission date May 11, 2021
Last update date May 11, 2021
Contact name GENESTIER Laurent
E-mail(s) laurent.genestier@inserm.fr
Organization name INSERM
Street address Faculté de Medecine Lyon Sud. 165 Chemin du petit Revoyet
City Oullins
ZIP/Postal code 69921
Country France
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (15)
GSM1544666 Resting T normal rep1
GSM1544667 Resting T normal rep2
GSM1544668 Resting T normal rep3
Relations
BioProject PRJNA728979

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE174257_RAW.tar 58.4 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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