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Series GSE17447 Query DataSets for GSE17447
Status Public on Oct 01, 2009
Title Expression data using esophageal epithelia from 3 month old-mice lacking the transcription factor Klf4
Organism Mus musculus
Experiment type Expression profiling by array
Summary Using the ED-L2 promoter of Epstein-Barr virus to drive Cre, we obtained tissue specific ablation of Klf4 in the squamous epithelia of the esophagus.
Using a functional genomic approach, we showed decreased expression of critical late-stage differentiation factors and identified alterations of several genes important in cellular differentiation.
 
Overall design For all experiments with ED-L2-Cre/Klf4loxp/loxp mice (mutant mice), sex-matched littermate Klf4loxp/loxp mice lacking the Cre transgene served as controls. 3 mutant mice and 3 controls were used.
 
Contributor(s) Katz JP, Tetreault MP
Citation(s) 20347813
Submission date Jul 31, 2009
Last update date Mar 04, 2019
Contact name Jonathan P. Katz
E-mail(s) jpkatz@pennmedicine.upenn.edu
Organization name University of Pennsylvania
Department Medicine/Gastroenterology
Street address 913 BRBII/III, 421 Curie Blvd.
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (6)
GSM435121 Mouse_Klf4Loxp/Loxp_3mo_rep1
GSM435122 Mouse_Klf4Loxp/Loxp_3mo_rep2
GSM435123 Mouse_Klf4Loxp/Loxp_3mo_rep3
Relations
BioProject PRJNA118873

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17447_RAW.tar 23.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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