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Series GSE17451 Query DataSets for GSE17451
Status Public on Aug 17, 2010
Title eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Organism Mus musculus
Experiment type Expression profiling by array
Summary Translational regulation plays a critical role in cell growth and proliferation, and its dysregulation results in cancer. Aberrant expression of the mRNA 5’cap-binding protein, eIF4E, has been implicated in cancer development and progression. eIF4E activity is promoted by phosphorylation. Here we show that “knock-in” mice in which eIF4E cannot be phosphorylated are resistant to tumorigenesis in a prostate cancer model. We identify multiple candidate genes involved in the resistance to oncogenic transformation. Importantly, phosphorylation of eIF4E is increased in hormone-refractory prostate cancer, the deadliest stage of the disease. Our results highlight eIF4E phosphorylation as a critical event in tumorigenesis.
 
Overall design Comaparison of total RNA and polysomal RNA from mouse embryo fibroblasts derived from WT and eIF4E-KI (non phosphorylatable eIF4E) mice
 
Contributor(s) Larsson O, Sonenberg N
Citation(s) 20679199
Submission date Jul 31, 2009
Last update date Jun 14, 2018
Contact name Ola Larsson
E-mail(s) ola.larsson@ki.se
Phone +46 (0)8 517 73280
Organization name Karolinska Institutet
Department Department of oncology-pathology
Street address CCK, R8:01
City Stockholm
ZIP/Postal code 171 76
Country Sweden
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM435171 Total RNA purified from MEFs derived from a EIF4E-KI mouse rep 1
GSM435172 Polysomal RNA purified from MEFs derived from a EIF4E-KI mouse rep 1
GSM435173 Total RNA purified from MEFs derived from a WT mouse rep 1
Relations
BioProject PRJNA118901

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17451_RAW.tar 3.1 Mb (http)(custom) TAR
GSE17451_non_normalized.txt.gz 1.1 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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