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Status |
Public on May 20, 2021 |
Title |
Altered Intercellular Communication and Extracellular Matrix Signaling as a Disease Mechanism in Human Hypertrophic Cardiomyopathy |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
To understand the interplay between cardiomyocyte and nonmyocyte cell types in human hypertrophic cardiomyopathy, single nuclei RNA-sequencing was performed on 9 myectomy specimens from HCM patients
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Overall design |
Myectomy specimens (samples 5-13) were sampled for single nuclei transcriptomic sequencing. Sample 5 was generated and sequenced on its own with NextSeq 550. Samples 6-13 were generated and sequenced togheter on a NovaSeq S4 run.
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Contributor(s) |
Larson A, Codden CJ, Chin MT |
Citation(s) |
35055131, 35338173, 37628806 |
Submission date |
May 19, 2021 |
Last update date |
Sep 14, 2023 |
Contact name |
Christina Codden |
E-mail(s) |
ccodden@tuftsmedicalcenter.org
|
Phone |
7632195132
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Organization name |
Tufts Medical Center
|
Department |
Molecular Cardiology Research Institute
|
Lab |
Chin Lab
|
Street address |
800 Washington Stree
|
City |
Boston |
State/province |
MA |
ZIP/Postal code |
02111 |
Country |
USA |
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Platforms (2) |
GPL21697 |
NextSeq 550 (Homo sapiens) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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Samples (9)
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Relations |
BioProject |
PRJNA731128 |
SRA |
SRP320495 |