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| Status |
Public on Mar 07, 2022 |
| Title |
Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We systemetically distinguished the effects of each class of sex-biasing factors on transcriptome regulation in liver and adipose tissues with the Four Core Genotype (FCG) mouse model. The results offers a tissue-specific account of the individual contribution of major sex-biasing factors to gene regulation.
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| Overall design |
We utilized the Four Core Genotype (FCG) mouse model with or without hormone replacement to distinguish the effects of each class of sex-biasing factors on transcriptome regulation (e.g., gene expression, molecular pathways, gene network organizations, etc.) in liver and adipose tissue.
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| Contributor(s) |
Blencowe M, Chen X, Zhao Y, Itoh Y, McQuillen CN, Han Y, Shou B, McClusky R, Reue K, Arnold AP, Yang X |
| Citation(s) |
35396276 |
| Submission date |
Jun 02, 2021 |
| Last update date |
Apr 11, 2022 |
| Contact name |
Montgomery Blencowe |
| E-mail(s) |
montyblencowe@g.ucla.edu
|
| Organization name |
UCLA
|
| Street address |
610 Charles E Young Drive East
|
| City |
Los Angeles |
| ZIP/Postal code |
90049 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (115)
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| Relations |
| BioProject |
PRJNA734621 |
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