|
| Status |
Public on Jun 10, 2021 |
| Title |
IRF8-dependent control of pDC terminal differentiation and MYC repression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
A switch from MYC expression in bone marrow progenitors to MYCL expression in terminal dendrtitic cell (DC) subsets occurs during DC development. The present study identifies the precise stage during DC development when this switch occurs, and identifies a role for IRF8 in control of this switch. IRF8 is found to be required for both MYC repression and MYCL induction during DC specification in vivo.
|
| |
|
| Overall design |
Splenic pDCs were isolated from WT and IRF8-deficient mice for expression microarray analysis.
|
| |
|
| Contributor(s) |
Anderson DA, Murphy KM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 09, 2021 |
| Last update date |
Jun 12, 2021 |
| Contact name |
David Alexander Anderson III |
| E-mail(s) |
davidandersoniii@wustl.edu
|
| Organization name |
Washington University School of Medicine
|
| Department |
Pathology and Immunology
|
| Lab |
Murphy
|
| Street address |
660. S Euclid Ave., Campus Box 8118
|
| City |
St. Louis |
| State/province |
Missouri |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA736457 |
Less...
More...