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| Status |
Public on Sep 27, 2009 |
| Title |
Transitions in infant learning are modulated by dopamine within the amygdala |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Behavioral transitions Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent.
Microarray results showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala.
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| Overall design |
8 day saline or corticosterone treated- or 12 day old untreated rat pups were trained with odor-shock pairings. Immediately after training pups were sacrificed and the amygdala dissected out. Controls were unpaired shock-odor groups.Paired and unpaired groups were processed together for each experimental condition. Paired and unpaired data were compared by ranked products.
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| Contributor(s) |
Barr G |
| Citation(s) |
19783994 |
| Submission date |
Aug 14, 2009 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Gordon A. Barr |
| E-mail(s) |
barrg@email.chop.edu
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| Phone |
267-426-9722
|
| Organization name |
Children's Hospital of Philadelphia
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| Department |
Anesthesiology and Critical Care Medicine
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| Lab |
907A ARC
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| Street address |
3615 Civic Center Blvd
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (2) |
| GPL341 |
[RAE230A] Affymetrix Rat Expression 230A Array |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA118603 |
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